
GLP-1 Medications: How Semaglutide and Tirzepatide Work
What these medications do to appetite and metabolism, who they're a fit for, and what results to expect month by month.
The Journal
Clear, physician-reviewed writing on weight loss, longevity, hormones, and sexual health, so you can make informed decisions about your care.
Featured

What these medications do to appetite and metabolism, who they're a fit for, and what results to expect month by month.
Medication appearance varies by pharmacy.
Weight Loss

What these medications do to appetite and metabolism, who they're a fit for, and what results to expect month by month.

Why some patients do better on smaller, slower-titrated doses, and how providers decide when a gentler ramp makes sense.

Appetite drops fast on GLP-1s, so what you eat matters more. A simple framework for hitting protein and fiber on less food.
Medication appearance varies by pharmacy.
Longevity

A grounded look at what's evidence-based in longevity medicine and what's hype, across the protocols we prescribe.

NAD+ is everywhere in longevity marketing. We separate the mechanisms with real data behind them from the wishful thinking.

How growth-hormone-releasing peptides differ from HGH itself, what they help with, and the monitoring that keeps them safe.
Medication appearance varies by pharmacy.
Hormones
Medication appearance varies by pharmacy.
Sexual Health

Sildenafil vs. tadalafil, daily vs. as-needed dosing, and when ED is a signal worth investigating further.

Onset, duration, and daily vs. as-needed dosing. A clear comparison to help you and your provider pick the better option.
Medication appearance varies by pharmacy.
Fitness
Medication appearance varies by pharmacy.
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